Prognostic Implications of NOTCH1 and FBXW7 Mutations in Adults With T-Cell Acute Lymphoblastic Leukemia Treated on the MRC UKALLXII/ECOG E2993 Protocol

PURPOSE: Notch pathway activation by mutations in either NOTCH1 and/or FBXW7 is one of the most common molecular events in T-cell acute lymphoblastic leukemia (T-ALL) and, in pediatric disease, predicts for favorable outcome. Their prognostic significance in adult T-ALL is unclear. We sought to eval...

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Detalhes bibliográficos
Main Authors: Mansour, Marc R., Sulis, Maria L., Duke, Veronique, Foroni, Letizia, Jenkinson, Sarah, Koo, Kenneth, Allen, Christopher G., Gale, Rosemary E., Buck, Georgina, Richards, Sue, Paietta, Elisabeth, Rowe, Jacob M., Tallman, Martin S., Goldstone, Anthony H., Ferrando, Adolfo A., Linch, David C.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Clinical Oncology 2009
Assuntos:
Original Reports
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2744275/
https://ncbi.nlm.nih.gov/pubmed/19635999
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1200/JCO.2009.22.0996
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