Development and preclinical evaluation of an alphavirus replicon particle vaccine for cytomegalovirus

We used a replication-incompetent, single-cycle, alphavirus replicon vector system to produce virus-like replicon particles (VRP) expressing the extracellular domain of human cytomegalovirus (CMV) glycoprotein B or a pp65/IE1 fusion protein. Efficient production methods were scaled to produce pilot...

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Main Authors: Reap, Elizabeth A., Morris, John, Dryga, Sergey A., Maughan, Maureen, Talarico, Todd, Esch, Robert E., Negri, Sarah, Burnett, Bruce, Graham, Andrew, Olmsted, Robert A., Chulay, Jeffrey D.
Format: Artigo
Jezik:Inglês
Izdano: 2007
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2744093/
https://ncbi.nlm.nih.gov/pubmed/17870214
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.vaccine.2007.08.016
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