Development and preclinical evaluation of an alphavirus replicon vaccine for influenza

We used a propagation-defective, single-cycle, alphavirus replicon vector system to produce virus-like replicon particles (VRP) expressing the hemagglutinin (HA) and neuraminidase (NA) proteins from influenza A/Wyoming/03/2003 (H3N2). Efficient production methods were scaled to produce pilot lots of...

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Hlavní autoři: Hubby, Bolyn, Talarico, Todd, Maughan, Maureen, Reap, Elizabeth A., Berglund, Peter, Kamrud, Kurt I., Copp, Laura, Lewis, Whitney, Cecil, Chad, Norberg, Pamela, Wagner, Jordan, Watson, Aubrey, Negri, Sarah, Burnett, Bruce K., Graham, Andrew, Smith, Jonathan F., Chulay, Jeffrey D.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2007
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2706696/
https://ncbi.nlm.nih.gov/pubmed/17961878
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.vaccine.2007.09.038
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