Mammalian P2X7 receptor pharmacology: comparison of recombinant mouse, rat and human P2X7 receptors

BACKGROUND AND PURPOSE: Acute activation of P2X7 receptors rapidly opens a non-selective cation channel. Sustained P2X7 receptor activation leads to the formation of cytolytic pores, mediated by downstream recruitment of hemichannels to the cell surface. Species- and single-nucleotide polymorphism-m...

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Autores principales: Donnelly-Roberts, Diana L, Namovic, Marian T, Han, Ping, Jarvis, Michael F
Formato: Artigo
Lenguaje:Inglês
Publicado: Blackwell Publishing Ltd 2009
Materias:
Research Papers
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2743839/
https://ncbi.nlm.nih.gov/pubmed/19558545
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1476-5381.2009.00233.x
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