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Structural evidence for consecutive Hel308-like modules in the spliceosomal ATPase Brr2
Brr2 is a DExD/H-box helicase responsible for U4/U6 unwinding during spliceosomal activation. Brr2 contains two helicase-like domains, each of which is followed by a Sec63 domain with unknown function. We determined the crystal structure of the second Sec63 domain, which unexpectedly resembles domai...
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| Main Authors: | , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2743687/ https://ncbi.nlm.nih.gov/pubmed/19525970 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.1625 |
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