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Brr2 plays a role in spliceosomal activation in addition to U4/U6 unwinding
Brr2 is a DExD/H-box RNA helicase that is responsible for U4/U6 unwinding, a critical step in spliceosomal activation. Brr2 is a large protein (∼250 kD) that consists of an N-terminal domain (∼500 residues) with unknown function and two Hel308-like modules that are responsible for RNA unwinding. Her...
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| Udgivet i: | Nucleic Acids Res |
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| Main Authors: | , , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Oxford University Press
2015
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4381053/ https://ncbi.nlm.nih.gov/pubmed/25670679 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkv062 |
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