Multiple functions of precursor BDNF to CNS neurons: negative regulation of neurite growth, spine formation and cell survival

BACKGROUND: Proneurotrophins and mature neurotrophins elicit opposite effects via the p75 neurotrophin receptor (p75(NTR)) and Trk tyrosine kinase receptors, respectively; however the molecular roles of proneurotrophins in the CNS are not fully understood. RESULTS: Based on two rare single nucleotid...

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Detalhes bibliográficos
Main Authors: Koshimizu, Hisatsugu, Kiyosue, Kazuyuki, Hara, Tomoko, Hazama, Shunsuke, Suzuki, Shingo, Uegaki, Koichi, Nagappan, Guhan, Zaitsev, Eugene, Hirokawa, Takatsugu, Tatsu, Yoshiro, Ogura, Akihiko, Lu, Bai, Kojima, Masami
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2009
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2743674/
https://ncbi.nlm.nih.gov/pubmed/19674479
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1756-6606-2-27
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