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Structure of the intact PPAR-γ–RXR-α nuclear receptor complex on DNA
Nuclear receptors are multi-domain transcription factors that bind to DNA elements from which they regulate gene expression. The peroxisome proliferator-activated receptors (PPARs) form heterodimers with the retinoid X receptor (RXR), and PPAR-γ has been intensively studied as a drug target because...
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| Main Authors: | , , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2008
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2743566/ https://ncbi.nlm.nih.gov/pubmed/19043829 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature07413 |
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