Synthesis and evaluation of an acyl-chain unsaturated analog of the Th2 biasing, immunostimulatory glycolipid, OCH

An α-galactosyl ceramide (α-GalCer) 2 was synthesized and evaluated for its ability to stimulate iNKT-cell proliferation and elicit T-helper cytokines, IL-4 and IFNγ. Compound 2 combines the acyl chain of the potent, Th2 biasing α-GalCer 1 with a sphingoid base of the same length as that found in OC...

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Autores principales: Velmourougane, Geetha, Raju, Ravinder, Bricard, Gabriel, Im, Jin S., Besra, Gurdyal S., Porcelli, Steven A., Howell, Amy R.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2009
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2743301/
https://ncbi.nlm.nih.gov/pubmed/19481452
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2009.05.042
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