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Synthesis and evaluation of 3”- and 4”-deoxy and -fluoro analogs of the immunostimulatory glycolipid, KRN7000
Four 3”- and 4”-deoxy and -fluorogalactosyl ceramides were synthesized, and their ability to stimulate iNKT cells, based on levels of IL-2 production, was assessed in three NKT cell receptor hybridomas. In two of the hybridomas, 1.2 and 2H4, all of the analogs were immunostimulatory, while in the 1....
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2710405/ https://ncbi.nlm.nih.gov/pubmed/19535248 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2009.06.005 |
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