Lactate promotes glioma migration by TGF-β2–dependent regulation of matrix metalloproteinase-2

Lactate dehydrogenase type A (LDH-A) is a key metabolic enzyme catalyzing pyruvate into lactate and is excessively expressed by tumor cells. Transforming growth factor-β2 (TGF-β2) is a key regulator of invasion in high-grade gliomas, partially by inducing a mesenchymal phenotype and by remodeling th...

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Detalhes bibliográficos
Main Authors: Baumann, Fusun, Leukel, Petra, Doerfelt, Anett, Beier, Christoph P., Dettmer, Katja, Oefner, Peter J., Kastenberger, Michael, Kreutz, Marina, Nickl-Jockschat, Thomas, Bogdahn, Ulrich, Bosserhoff, Anja-Katrin, Hau, Peter
Formato: Artigo
Idioma:Inglês
Publicado em: Duke University Press 2009
Assuntos:
Basic and Translational Investigations
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2743217/
https://ncbi.nlm.nih.gov/pubmed/19033423
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1215/15228517-2008-106
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