Plasminogen Activator Inhibitor-1 Regulates Integrin αvβ3 Expression and Autocrine Transforming Growth Factor β Signaling

Fibrosis is characterized by elevated transforming growth factor β (TGFβ) signaling, resulting in extracellular matrix accumulation and increased PAI-1 (plasminogen activator inhibitor) expression. PAI-1 induces the internalization of urokinase plasminogen activator/receptor and integrin αvβ3 from t...

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Bibliografiset tiedot
Päätekijät: Pedroja, Benjamin S., Kang, Leah E., Imas, Alex O., Carmeliet, Peter, Bernstein, Audrey M.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: American Society for Biochemistry and Molecular Biology 2009
Aiheet:
Molecular Basis of Cell and Developmental Biology
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC2742836/
https://ncbi.nlm.nih.gov/pubmed/19487690
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.018804
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