Ectopic Runx2 Expression in Mammary Epithelial Cells Disrupts Formation of Normal Acini Structure: Implications for Breast Cancer Progression

The transcription factor Runx2 is highly expressed in breast cancer cells compared to mammary epithelial cells and contributes to metastasis. Here we directly show that Runx2 expression promotes a tumor cell phenotype of mammary acini in three dimensional culture. Human mammary epithelial cells (MCF...

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Main Authors: Pratap, Jitesh, Imbalzano, Karen M., Underwood, Jean M., Cohet, Nathalie, Gokul, Karthiga, Akech, Jacqueline, van Wijnen, Andre J., Stein, Janet L., Imbalzano, Anthony N., Nickerson, Jeffrey A., Lian, Jane B., Stein, Gary S.
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2742766/
https://ncbi.nlm.nih.gov/pubmed/19690135
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-09-1471
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