Ectopic Runx2 Expression in Mammary Epithelial Cells Disrupts Formation of Normal Acini Structure: Implications for Breast Cancer Progression

The transcription factor Runx2 is highly expressed in breast cancer cells compared to mammary epithelial cells and contributes to metastasis. Here we directly show that Runx2 expression promotes a tumor cell phenotype of mammary acini in three dimensional culture. Human mammary epithelial cells (MCF...

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Autori principali: Pratap, Jitesh, Imbalzano, Karen M., Underwood, Jean M., Cohet, Nathalie, Gokul, Karthiga, Akech, Jacqueline, van Wijnen, Andre J., Stein, Janet L., Imbalzano, Anthony N., Nickerson, Jeffrey A., Lian, Jane B., Stein, Gary S.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2009
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2742766/
https://ncbi.nlm.nih.gov/pubmed/19690135
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-09-1471
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