Bacillus anthracis Lethal Toxin Disrupts TCR Signaling in CD1d-Restricted NKT Cells Leading to Functional Anergy

Exogenous CD1d-binding glycolipid (α-Galactosylceramide, α-GC) stimulates TCR signaling and activation of type-1 natural killer–like T (NKT) cells. Activated NKT cells play a central role in the regulation of adaptive and protective immune responses against pathogens and tumors. In the present study...

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Detalhes bibliográficos
Main Authors: Joshi, Sunil K., Lang, Gillian A., Larabee, Jason L., Devera, T. Scott, Aye, Lindsay M., Shah, Hemangi B., Ballard, Jimmy D., Lang, Mark L.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2009
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2742733/
https://ncbi.nlm.nih.gov/pubmed/19779559
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1000588
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