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Sulfonylureas Improve Outcome in Patients With Type 2 Diabetes and Acute Ischemic Stroke

BACKGROUND AND PURPOSE: The sulfonylurea receptor 1-regulated NC(Ca-ATP) channel is upregulated in rodent models of stroke with block of the channel by the sulfonylurea, glibenclamide (glyburide), significantly reducing mortality, cerebral edema, and infarct volume. We hypothesized that patients wit...

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Detalhes bibliográficos
Main Authors: Kunte, Hagen, Schmidt, Sein, Eliasziw, Michael, del Zoppo, Gregory J., Simard, J. Marc, Masuhr, Florian, Weih, Markus, Dirnagl, Ulrich
Formato: Artigo
Idioma:Inglês
Publicado em: 2007
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2742413/
https://ncbi.nlm.nih.gov/pubmed/17673715
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/STROKEAHA.107.482216
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