Improved tumor immunity using anti-tyrosinase related protein-1 mAb combined with DNA vaccines in murine melanoma

Passive immunization with monoclonal antibody TA99 targeting melanoma differentiation antigen Tyrp1 (tyrosinase related protein-1, gp75) and active immunization with plasmid DNA encoding altered Tyrp1 both mediate tumor immunity in the B16 murine melanoma model. We report here that TA99 enhances Tyr...

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Main Authors: Saenger, Yvonne M., Li, Yanyun, Chiou, Karoline C., Chan, Brian, Rizzuto, Gabrielle, Terzulli, Stephanie L., Merghoub, Taha, Houghton, Alan N., Wolchok, Jedd D.
Formato: Artigo
Idioma:Inglês
Publicado: 2008
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2742375/
https://ncbi.nlm.nih.gov/pubmed/19047169
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-08-2233
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