REACTIONS OF PEROXYNITRITE WITH URIC ACID: FORMATION OF REACTIVE INTERMEDIATES, ALKYLATED PRODUCTS AND TRIURET, AND IN VIVO PRODUCTION OF TRIURET UNDER CONDITIONS OF OXIDATIVE STRESS

Hyperuricemia is associated with hypertension, metabolic syndrome, preeclampsia, cardiovascular disease and renal disease, all conditions associated with oxidative stress. We hypothesized that uric acid, a known antioxidant, might become prooxidative following its reaction with oxidants; and, thereb...

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Main Authors: Gersch, Christine, Palii, Sergiu P., Imaram, Witcha, Kim, Kyung Mee, Karumanchi, S. Ananth, Angerhofer, Alexander, Johnson, Richard J., Henderson, George N.
Format: Artigo
Jezik:Inglês
Izdano: 2009
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2742358/
https://ncbi.nlm.nih.gov/pubmed/19219741
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15257770902736400
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