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Simultaneous determination of uric acid metabolites allantoin, 6-aminouracil, and triuret in human urine using liquid chromatography–mass spectrometry

Uric acid (UA) can be directly converted to allantoin enzymatically by uricase in most mammals except humans or by reaction with superoxide. UA can react directly with nitric oxide to generate 6-aminouracil and with peroxynitrite to yield triuret; both of these metabolites have been identified in bi...

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Detalhes bibliográficos
Main Authors: Kim, Kyung Mee, Henderson, George N., Frye, Reginald F., Galloway, Cheryl D., Brown, Nancy J., Segal, Mark S., Imaram, Witcha, Angerhofer, Alexander, Johnson, Richard J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2684329/
https://ncbi.nlm.nih.gov/pubmed/19081307
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jchromb.2008.11.029
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