Valproic Acid and Other HDAC Inhibitors Induce Microglial Apoptosis and Attenuate Lipopolysaccharide- induced Dopaminergic Neurotoxicity

Valproic acid (VPA), a widely prescribed drug for seizures and bipolar disorder, has been shown to be an inhibitor of histone deacetylase (HDAC). Our previous study has demonstrated that VPA pretreatment reduces lipopolysaccharide (LPS)-induced dopaminergic (DA) neurotoxicity through the inhibition...

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Bibliographische Detailangaben
Hauptverfasser: Chen, Po See, Wang, Chao-Chuan, Bortner, Carl D., Peng, Giia-Sheun, Wu, Xuefei, Pang, Hao, Lu, Ru-Band, Gean, Po-Wu, Chuang, De-Maw, Hong, Jau-Shyong
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2007
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2741413/
https://ncbi.nlm.nih.gov/pubmed/17850978
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuroscience.2007.06.053
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