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Dependence of Hearing Changes on the Dose of Intratympanically-Applied Gentamicin: A Metaanalysis using Mathematical Simulations of Clinical Drug Delivery Protocols
OBJECTIVE: To establish safe dosing protocols for the treatment of Meniere’s patients with intratympanic gentamicin. STUDY DESIGN: A validated computer model of gentamicin dispersion in the inner ear fluids was used to calculate cochlear drug levels resulting from specific clinical delivery protocol...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2741178/ https://ncbi.nlm.nih.gov/pubmed/18806480 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/MLG.0b013e31817d01cd |
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