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Catalytic and ligand-binding characteristics of Plasmodium falciparum serine hydroxymethyltransferase

The plant-like, bifunctional dihydrofolate reductase-thymidylate synthase (DHFR-TS) from malaria parasites has been a good target for drug development. Dihydrofolate reductase (DHFR) is inhibited by clinically established antimalarials, pyrimethamine and cycloguanil. Thymidylate synthase (TS) is the...

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書誌詳細
主要な著者: Pang, Cullen KT, Hunter, Joshua H., Gujjar, Ramesh, Podutoori, Ramulu, Bowman, Julie, Mudeppa, Devaraja G., Rathod, Pradipsinh K.
フォーマット: Artigo
言語:Inglês
出版事項: 2009
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC2741015/
https://ncbi.nlm.nih.gov/pubmed/19591883
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molbiopara.2009.06.011
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