Catalytic and ligand-binding characteristics of Plasmodium falciparum serine hydroxymethyltransferase

The plant-like, bifunctional dihydrofolate reductase-thymidylate synthase (DHFR-TS) from malaria parasites has been a good target for drug development. Dihydrofolate reductase (DHFR) is inhibited by clinically established antimalarials, pyrimethamine and cycloguanil. Thymidylate synthase (TS) is the...

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Detalhes bibliográficos
Main Authors: Pang, Cullen KT, Hunter, Joshua H., Gujjar, Ramesh, Podutoori, Ramulu, Bowman, Julie, Mudeppa, Devaraja G., Rathod, Pradipsinh K.
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2741015/
https://ncbi.nlm.nih.gov/pubmed/19591883
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molbiopara.2009.06.011
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