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EDEM1 recognition and delivery of misfolded proteins to the SEL1L-containing ERAD complex
Terminally misfolded or unassembled secretory proteins are retained in the endoplasmic reticulum (ER) and subsequently cleared by the ER-associated degradation (ERAD) pathway. The degradation of ERAD substrates involves mannose trimming of N-linked glycans, however the mechanisms of substrate recogn...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2740909/ https://ncbi.nlm.nih.gov/pubmed/19524542 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2009.05.018 |
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