Plasminogen Substrate Recognition by the Streptokinase-Plasminogen Catalytic Complex Is Facilitated by Arg(253), Lys(256), and Lys(257) in the Streptokinase β-Domain and Kringle 5 of the Substrate

Streptokinase (SK) conformationally activates the central zymogen of the fibrinolytic system, plasminogen (Pg). The SK·Pg* catalytic complex binds Pg as a specific substrate and cleaves it into plasmin (Pm), which binds SK to form the SK·Pm complex that propagates Pm generation. Catalytic complex fo...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Tharp, Anthony C., Laha, Malabika, Panizzi, Peter, Thompson, Michael W., Fuentes-Prior, Pablo, Bock, Paul E.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2009
Assuntos:
Enzyme Catalysis and Regulation
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2740577/
https://ncbi.nlm.nih.gov/pubmed/19473980
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.005512
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados