Plasminogen Substrate Recognition by the Streptokinase-Plasminogen Catalytic Complex Is Facilitated by Arg(253), Lys(256), and Lys(257) in the Streptokinase β-Domain and Kringle 5 of the Substrate

Streptokinase (SK) conformationally activates the central zymogen of the fibrinolytic system, plasminogen (Pg). The SK·Pg* catalytic complex binds Pg as a specific substrate and cleaves it into plasmin (Pm), which binds SK to form the SK·Pm complex that propagates Pm generation. Catalytic complex fo...

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Bibliographische Detailangaben
Hauptverfasser: Tharp, Anthony C., Laha, Malabika, Panizzi, Peter, Thompson, Michael W., Fuentes-Prior, Pablo, Bock, Paul E.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2009
Schlagworte:
Enzyme Catalysis and Regulation
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2740577/
https://ncbi.nlm.nih.gov/pubmed/19473980
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.005512
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