Phosphorylation of RACK1 on Tyrosine 52 by c-Abl Is Required for Insulin-like Growth Factor I-mediated Regulation of Focal Adhesion Kinase

Focal Adhesion Kinase (FAK) activity is controlled by growth factors and adhesion signals in tumor cells. The scaffolding protein RACK1 (receptor for activated C kinases) integrates insulin-like growth factor I (IGF-I) and integrin signaling, but whether RACK1 is required for FAK function is unknown...

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Detalhes bibliográficos
Main Authors: Kiely, Patrick A., Baillie, George S., Barrett, Robert, Buckley, Deirdre A., Adams, David R., Houslay, Miles D., O'Connor, Rosemary
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2009
Assuntos:
Mechanisms of Signal Transduction
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2740452/
https://ncbi.nlm.nih.gov/pubmed/19423701
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.017640
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