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Mechanism by which a Glutamine to Leucine Substitution at Residue 509 in the Ribonuclease H Domain of HIV-1 Reverse Transcriptase Confers Zidovudine Resistance

We recently reported that zidovudine (AZT) selected for the Q509L mutation in the ribonuclease H (RNase H) domain of HIV-1 reverse transcriptase (RT), which increases resistance to AZT in combination with the thymidine analogue mutations D67N, K70R, and T215F. In the current study, we have defined t...

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Bibliografiske detaljer
Main Authors: Brehm, Jessica H., Mellors, John W., Sluis-Cremer, Nicolas
Format: Artigo
Sprog:Inglês
Udgivet: 2008
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2740331/
https://ncbi.nlm.nih.gov/pubmed/19067547
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi8014778
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