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Changes in cultured endothelial cell glycosaminoglycans under hyperglycemic conditions and the effect of insulin and heparin

BACKGROUND: Heparan sulfate proteoglycans (HSPGs) contain glycosaminoglycan (GAG) chains made primarily of heparan sulfate (HS). Hyperglycemia in diabetes leads to endothelial injury and nephropathy, retinopathy and atherosclerosis. Decreased HSPG may contribute to diabetic endothelial injury. Decre...

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Hlavní autoři: Han, Juying, Zhang, Fuming, Xie, Jin, Linhardt, Robert J, Hiebert, Linda M
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2009
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2739842/
https://ncbi.nlm.nih.gov/pubmed/19695080
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1475-2840-8-46
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