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Pseudo-hyperphosphorylation causing AD-like changes in tau has significant effects on its polymerization
The microtubule-associated protein tau, in a hyperphosphorylated form, aggregates into insoluble paired-helical filaments (PHFs) in Alzheimer’s disease (AD) and other tauopathies. In AD, there are approximately 8 mol of phosphate per mol of tau distributed among approximately 30 PHF phosphorylation...
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| Main Authors: | , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
2009
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2739831/ https://ncbi.nlm.nih.gov/pubmed/19459590 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi900602h |
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