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Activation of PXR induces hypercholesterolemia in wild-type and accelerates atherosclerosis in apoE deficient mice

The nuclear hormone receptor pregnane X receptor (PXR; also called SXR) functions as a xenobiotic sensor to coordinately regulate xenobiotic metabolism via transcriptional regulation of xenobiotic-detoxifying enzymes and transporters. Although many clinically relevant PXR ligands have been shown to...

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Detalhes bibliográficos
Main Authors: Zhou, Changcheng, King, Nakesha, Chen, Kwan Y., Breslow, Jan L.
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Biochemistry and Molecular Biology 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2739759/
https://ncbi.nlm.nih.gov/pubmed/19436068
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.M800608-JLR200
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