Cargando...

Host-deficiency in Vav 2/3 guanine nucleotide exchange factors impairs tumor growth, survival, and angiogenesis in vivo

Vav guanine nucleotide exchange factors (GEFs) modulate changes in cytoskeletal organization through activation of Rho, Rac, and Cdc42 small GTPases. While Vav1 expression is restricted to the immune system, Vav2 and 3 are expressed in several tissues, including highly vascularized organs. Here, we...

Descrición completa

Gardado en:
Detalles Bibliográficos
Main Authors: Brantley-Sieders, Dana M., Zhuang, Guanglei, Vaught, David, Freeman, Tanner, Hwang, Yoonha, Hicks, Donna, Chen, Jin
Formato: Artigo
Idioma:Inglês
Publicado: 2009
Assuntos:
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2739740/
https://ncbi.nlm.nih.gov/pubmed/19435813
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1541-7786.MCR-08-0401
Tags: Engadir etiqueta
Sen Etiquetas, Sexa o primeiro en etiquetar este rexistro!