Recurrent Chromosomal Rearrangements Implicate Oncogenes Contributing to T-Cell Lymphomagenesis in Lck-MyrAkt2 Transgenic Mice

The oncogene v-akt was isolated from a retrovirus that induced naturally occurring thymic lymphomas in AKR mice. We hypothesized that constitutive activation of Akt2 could serve as a first hit for the clonal expansion of malignant T-cells by promoting cell survival and genomic instability, leading t...

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Bibliographic Details
Main Authors: Timakhov, Roman A., Tan, Yinfei, Rao, Mamta, Liu, Zemin, Altomare, Deborah A., Pei, Jianming, Wiest, David L., Favorova, Olga O., Knepper, Janice E., Testa, Joseph R.
Format: Artigo
Language:Inglês
Published: 2009
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2739734/
https://ncbi.nlm.nih.gov/pubmed/19530243
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/gcc.20683
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