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Recurrent Chromosomal Rearrangements Implicate Oncogenes Contributing to T-Cell Lymphomagenesis in Lck-MyrAkt2 Transgenic Mice
The oncogene v-akt was isolated from a retrovirus that induced naturally occurring thymic lymphomas in AKR mice. We hypothesized that constitutive activation of Akt2 could serve as a first hit for the clonal expansion of malignant T-cells by promoting cell survival and genomic instability, leading t...
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| Main Authors: | , , , , , , , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2009
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2739734/ https://ncbi.nlm.nih.gov/pubmed/19530243 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/gcc.20683 |
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