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Kinetic basis of partial agonism at NMDA receptors
Activation of ligand-gated channels is initiated by the binding of small molecules at extracellular sites and culminates with the opening of a membrane-embedded pore. To investigate how perturbations at ligand-binding domains influence the gating reaction, we examined current traces recorded from in...
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| Main Authors: | , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
2009
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2739723/ https://ncbi.nlm.nih.gov/pubmed/19648915 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nn.2361 |
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