Crystal Structure of Miner1: The Redox Active 2Fe-2S Protein Causative in Wolfram Syndrome 2

The endoplasmic reticulum protein Miner1 is essential for health and longevity. Mis-splicing of CISD2, which codes for Miner1, is causative in Wolfram Syndrome 2 (WFS2) resulting in early onset optic atrophy, diabetes mellitus, deafness and decreased lifespan. In knock-out studies, disruption of CIS...

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Detalhes bibliográficos
Main Authors: Conlan, Andrea R., Axelrod, Herbert L., Cohen, Aina E., Abresch, Edward C., Zuris, John, Yee, David, Nechushtai, Rachel, Jennings, Patricia A., Paddock, Mark L.
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2739586/
https://ncbi.nlm.nih.gov/pubmed/19580816
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2009.06.079
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