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Inhibition of kappa opioid receptors attenuated increased cocaine intake in rats with extended access to cocaine

OBJECTIVE: Previous studies demonstrated that the dynorphin/κ opioid system was up-regulated upon repeated cocaine self-administration. In the present study, we tested the hypothesis that increased cocaine self-administration with extended access was associated with increased activity of the κ opioi...

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Autori principali: Wee, Sunmee, Orio, Laura, Ghirmai, Senait, Cashman, John R., Koob, George F.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2009
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2739447/
https://ncbi.nlm.nih.gov/pubmed/19484223
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00213-009-1563-y
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