Discovery of Potent Non-urea Inhibitors of Soluble Epoxide Hydrolase

Soluble epoxide hydrolase (sEH) is a novel target for the treatment of hypertension and vascular inflammation. A new class of potent non-urea sEH inhibitors was identified via high throughput screening (HTS) and chemical modification. IC(50)s of the most potent compounds range from micromolar to low...

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Detalhes bibliográficos
Main Authors: Xie, Yuli, Liu, Yidong, Gong, Gangli, Smith, Deborah H., Yan, Fang, Rinderspacher, Alison, Feng, Yan, Zhu, Zhengxiang, Li, Xiangpo, Deng, Shi-Xian, Branden, Lars, Vidović, Dušica, Chung, Caty, Schürer, Stephan, Morisseau, Christophe, Hammock, Bruce D., Landry, Donald W.
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2738751/
https://ncbi.nlm.nih.gov/pubmed/19303288
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2008.09.066
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