Level and course of FEV(1 )in relation to polymorphisms in NFE2L2 and KEAP1 in the general population

BACKGROUND: The metabolism of xenobiotics plays an essential role in smoking related lung function loss and development of Chronic Obstructive Pulmonary Disease. Nuclear Factor Erythroid 2-Like 2 (NFE2L2 or NRF2) and its cytosolic repressor Kelch-like ECH-associated protein-1 (KEAP1) regulate transc...

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Bibliografiske detaljer
Main Authors: Siedlinski, Mateusz, Postma, Dirkje S, Boer, Jolanda MA, van der Steege, Gerrit, Schouten, Jan P, Smit, Henriette A, Boezen, H Marike
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2009
Fag:
Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2738671/
https://ncbi.nlm.nih.gov/pubmed/19671143
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1465-9921-10-73
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