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Complementation of diverse HIV-1 Env defects through cooperative subunit interactions: a general property of the functional trimer

BACKGROUND: The HIV-1 Env glycoprotein mediates virus entry by catalyzing direct fusion between the virion membrane and the target cell plasma membrane. Env is composed of two subunits: gp120, which binds to CD4 and the coreceptor, and gp41, which is triggered upon coreceptor binding to promote the...

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Autors principals: Salzwedel, Karl, Berger, Edward A
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2009
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2738651/
https://ncbi.nlm.nih.gov/pubmed/19671162
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1742-4690-6-75
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