Chargement en cours...

X-ray structure of the ternary MTX•NADPH complex of the anthrax dihydrofolate reductase: a pharmacophore for dual-site inhibitor design

For reasons of bioterrorism and drug resistance, it is imperative to identify and develop new molecular points of intervention against anthrax. Dihydrofolate reductase (DHFR) is a highly conserved enzyme and an established target in a number of species for a variety of chemotherapeutic programs. Rec...

Description complète

Enregistré dans:
Détails bibliographiques
Auteurs principaux: Bennett, Brad C., Wan, Qun, Ahmad, Md Faiz, Dealwis, Chris G.
Format: Artigo
Langue:Inglês
Publié: 2009
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2738603/
https://ncbi.nlm.nih.gov/pubmed/19374017
Tags: Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!