Endogenous activated protein C limits cancer cell extravasation through sphingosine-1-phosphate receptor 1–mediated vascular endothelial barrier enhancement

Activated protein C (APC) has both anticoagulant activity and direct cell-signaling properties. APC has been reported to promote cancer cell migration/invasion and to inhibit apoptosis and therefore may exacerbate metastasis. Opposing these activities, APC signaling protects the vascular endothelial...

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Autores principales: Van Sluis, Geerte L., Niers, Tatjana M.H., Esmon, Charles T., Tigchelaar, Wikky, Richel, Dick J., Buller, Harry R., Van Noorden, Cornelis J.F., Spek, C. Arnold
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society of Hematology 2009
Materias:
Vascular Biology
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2738579/
https://ncbi.nlm.nih.gov/pubmed/19571314
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2009-04-217679
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