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Endogenous activated protein C is essential for immune-mediated cancer cell elimination from the circulation

Fibrinogen and platelets play an important role in cancer cell survival in the circulation by protecting cancer cells from the immune system. Moreover, endogenous activated protein C (APC) limits cancer cell extravasation due to sphingosine-1-phosphate receptor-1 (S(1)P(1)) and VE-cadherin-dependent...

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Main Authors: Van Sluis, GL, Brüggemann, LW, Esmon, CT., Kamphuisen, PW, Richel, DJ, Büller, HR, van Noorden, CJF, Spek, CA
格式: Artigo
語言:Inglês
出版: 2011
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3159049/
https://ncbi.nlm.nih.gov/pubmed/21420234
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.canlet.2011.02.038
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