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Positive Selection Pressure Introduces Secondary Mutations at Gag Cleavage Sites in Human Immunodeficiency Virus Type 1 Harboring Major Protease Resistance Mutations

Human immunodeficiency virus type 1 (HIV-1) protease inhibitors (PIs) specifically target the HIV-1 protease enzyme. Mutations in the enzyme can result in PI resistance (termed PI mutations); however, mutations in the HIV-1 gag region, the substrate for the protease enzyme, might also lead to PI res...

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Библиографические подробности
Главные авторы: Banke, Søren, Lillemark, Marie R., Gerstoft, Jan, Obel, Niels, Jørgensen, Louise B.
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Microbiology (ASM) 2009
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC2738184/
https://ncbi.nlm.nih.gov/pubmed/19515784
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00003-09
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