The Adenovirus E4orf4 Protein Induces G(2)/M Arrest and Cell Death by Blocking Protein Phosphatase 2A Activity Regulated by the B55 Subunit

Human adenovirus E4orf4 protein is toxic in human tumor cells. Its interaction with the Bα subunit of protein phosphatase 2A (PP2A) is critical for cell killing; however, the effect of E4orf4 binding is not known. Bα is one of several mammalian B-type regulatory subunits that form PP2A holoenzymes w...

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Detalhes bibliográficos
Main Authors: Li, Suiyang, Brignole, Claudine, Marcellus, Richard, Thirlwell, Sara, Binda, Olivier, McQuoid, Monica J., Ashby, Danita, Chan, Helen, Zhang, Zhiying, Miron, Marie-Joëlle, Pallas, David C., Branton, Philip E.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2009
Assuntos:
Virus-Cell Interactions
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2738146/
https://ncbi.nlm.nih.gov/pubmed/19535438
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00711-09
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