Antibiotic Treatment of Clostridium difficile Carrier Mice Triggers a Supershedder State, Spore-Mediated Transmission, and Severe Disease in Immunocompromised Hosts

Clostridium difficile persists in hospitals by exploiting an infection cycle that is dependent on humans shedding highly resistant and infectious spores. Here we show that human virulent C. difficile can asymptomatically colonize the intestines of immunocompetent mice, establishing a carrier state t...

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محفوظ في:
التفاصيل البيبلوغرافية
المؤلفون الرئيسيون: Lawley, Trevor D., Clare, Simon, Walker, Alan W., Goulding, David, Stabler, Richard A., Croucher, Nicholas, Mastroeni, Piero, Scott, Paul, Raisen, Claire, Mottram, Lynda, Fairweather, Neil F., Wren, Brendan W., Parkhill, Julian, Dougan, Gordon
التنسيق: Artigo
اللغة:Inglês
منشور في: American Society for Microbiology (ASM) 2009
الموضوعات:
Bacterial Infections
الوصول للمادة أونلاين:https://ncbi.nlm.nih.gov/pmc/articles/PMC2737984/
https://ncbi.nlm.nih.gov/pubmed/19564382
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.00558-09
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