Antibiotic Treatment of Clostridium difficile Carrier Mice Triggers a Supershedder State, Spore-Mediated Transmission, and Severe Disease in Immunocompromised Hosts

Clostridium difficile persists in hospitals by exploiting an infection cycle that is dependent on humans shedding highly resistant and infectious spores. Here we show that human virulent C. difficile can asymptomatically colonize the intestines of immunocompetent mice, establishing a carrier state t...

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Main Authors: Lawley, Trevor D., Clare, Simon, Walker, Alan W., Goulding, David, Stabler, Richard A., Croucher, Nicholas, Mastroeni, Piero, Scott, Paul, Raisen, Claire, Mottram, Lynda, Fairweather, Neil F., Wren, Brendan W., Parkhill, Julian, Dougan, Gordon
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology (ASM) 2009
Teme:
Bacterial Infections
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2737984/
https://ncbi.nlm.nih.gov/pubmed/19564382
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.00558-09
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