Antibiotic Treatment of Clostridium difficile Carrier Mice Triggers a Supershedder State, Spore-Mediated Transmission, and Severe Disease in Immunocompromised Hosts

Clostridium difficile persists in hospitals by exploiting an infection cycle that is dependent on humans shedding highly resistant and infectious spores. Here we show that human virulent C. difficile can asymptomatically colonize the intestines of immunocompetent mice, establishing a carrier state t...

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Detalhes bibliográficos
Main Authors: Lawley, Trevor D., Clare, Simon, Walker, Alan W., Goulding, David, Stabler, Richard A., Croucher, Nicholas, Mastroeni, Piero, Scott, Paul, Raisen, Claire, Mottram, Lynda, Fairweather, Neil F., Wren, Brendan W., Parkhill, Julian, Dougan, Gordon
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2009
Assuntos:
Bacterial Infections
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2737984/
https://ncbi.nlm.nih.gov/pubmed/19564382
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.00558-09
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