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Cell-type Specific Regulation of Gene Expression by Simian Virus 40 T antigens
SV40 transforms cells through the action of two oncoproteins, large T antigen and small t antigen. Small t antigen targets phosphatase PP2A, while large T antigen stimulates cell proliferation and survival by action on multiple proteins, including the tumor suppressors Rb and p53. Large T antigen al...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2737743/ https://ncbi.nlm.nih.gov/pubmed/19201438 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.virol.2008.12.038 |
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