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Intracellular zinc inhibits KCC2 transporter activity
We report that KCC2 activity, monitored with wide–field fluorescence, is inhibited by intracellular Zn(2+), a key component of neuronal injury. Zn(2+)–mediated KCC2 inhibition produced a depolarizing shift of GABA(A) reversal potentials in rat neurons. Moreover, oxygen–glucose deprivation attenuated...
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| Главные авторы: | , , , , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2009
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2737597/ https://ncbi.nlm.nih.gov/pubmed/19430470 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nn.2316 |
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