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A New Resorufin-Based Alpha-Glucosidase Assay for High Throughput Screening
Mutations in α-glucosidase cause accumulation of glycogen in lysosomes resulting in Pompe disease, a lysosomal storage disorder. Small molecule chaperones that bind to enzyme proteins and correct the misfolding and mistrafficking of mutant proteins have emerged as a new therapeutic approach for the...
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| 主要な著者: | , , , , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2009
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2737366/ https://ncbi.nlm.nih.gov/pubmed/19371716 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ab.2009.04.010 |
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