A New Resorufin-Based Alpha-Glucosidase Assay for High Throughput Screening

Mutations in α-glucosidase cause accumulation of glycogen in lysosomes resulting in Pompe disease, a lysosomal storage disorder. Small molecule chaperones that bind to enzyme proteins and correct the misfolding and mistrafficking of mutant proteins have emerged as a new therapeutic approach for the...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Motabar, Omid, Shi, Zhen-Dan, Goldin, Ehud, Liu, Ke, Southall, Noel, Sidransky, Ellen, Austin, Christopher P., Griffiths, Gary L., Zheng, Wei
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2009
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC2737366/
https://ncbi.nlm.nih.gov/pubmed/19371716
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ab.2009.04.010
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