A New Resorufin-Based Alpha-Glucosidase Assay for High Throughput Screening

Mutations in α-glucosidase cause accumulation of glycogen in lysosomes resulting in Pompe disease, a lysosomal storage disorder. Small molecule chaperones that bind to enzyme proteins and correct the misfolding and mistrafficking of mutant proteins have emerged as a new therapeutic approach for the...

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Autores principales: Motabar, Omid, Shi, Zhen-Dan, Goldin, Ehud, Liu, Ke, Southall, Noel, Sidransky, Ellen, Austin, Christopher P., Griffiths, Gary L., Zheng, Wei
Formato: Artigo
Lenguaje:Inglês
Publicado: 2009
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2737366/
https://ncbi.nlm.nih.gov/pubmed/19371716
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ab.2009.04.010
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