Assessment of allele-specific gene silencing by RNA interference with mutant and wild-type reporter alleles

Allele-specific gene silencing by RNA interference (RNAi) is therapeutically useful for specifically suppressing the expression of alleles associated with disease. To realize such allele-specific RNAi (ASPRNAi), the design and assessment of small interfering RNA (siRNA) duplexes conferring ASP-RNAi...

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Bibliographische Detailangaben
Hauptverfasser: Ohnishi, Yusuke, Tokunaga, Katsushi, Kaneko, Kiyotoshi, Hohjoh, Hirohiko
Format: Artigo
Sprache:Inglês
Veröffentlicht: Library Publishing Media 2006
Schlagworte:
New Methods and Technologies
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2737209/
https://ncbi.nlm.nih.gov/pubmed/19771217
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