Dissection of PIM serine/threonine kinases in FLT3-ITD–induced leukemogenesis reveals PIM1 as regulator of CXCL12–CXCR4-mediated homing and migration

FLT3-ITD–mediated leukemogenesis is associated with increased expression of oncogenic PIM serine/threonine kinases. To dissect their role in FLT3-ITD–mediated transformation, we performed bone marrow reconstitution assays. Unexpectedly, FLT3-ITD cells deficient for PIM1 failed to reconstitute lethal...

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Autori principali: Grundler, Rebekka, Brault, Laurent, Gasser, Christelle, Bullock, Alex N., Dechow, Tobias, Woetzel, Sabine, Pogacic, Vanda, Villa, Antonello, Ehret, Sabine, Berridge, Georgina, Spoo, Anke, Dierks, Christine, Biondi, Andrea, Knapp, Stefan, Duyster, Justus, Schwaller, Juerg
Natura: Artigo
Lingua:Inglês
Pubblicazione: The Rockefeller University Press 2009
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2737164/
https://ncbi.nlm.nih.gov/pubmed/19687226
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20082074
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